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Challenges with obtaining the arterial input function to model glucose concentration in the parenchyma, its transport and utilization, the relatively long imaging time from application of multiple long TR saturation pulses, and importantly the lack of validation of CEST agents for BBB, present limitations its routine clinical use (Kogan et al., 2013

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5.2 Signaling from the brain to the gut microbiota The ANS regulate gut functions including regional motility, secretion of gastric acid, mucus, bicarbonate, gut peptides, antimicrobial peptides, epithelial fluid maintenance, intestinal permeability, and mucosal immune response