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GSSG generated in these processes can be either recycled to GSH by a NADPH-dependent reaction, catalyzed by GR 3 , or pumped out of the cell by ATP-dependent processes, with multidrug resistance-associated protein-1 (MRP-1) being the major pathway for GSSG efflux 33
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No standardised detection window exists, and metabolite detection may extend well beyond the compound's short plasma half-life, making any clearance time estimate unreliable for competitive athletes
However, Trolox can be used as a standard in assays performed in non-aqueous media, estimating hydrophobic antioxidants
Lambou et al., 2010)
