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The overall response rate (ORR) for CM patients to ipilimumab, nivolumab, pembrolizumab and atezolizumab is 12%, 40%, 33% and 30% respectively (167169), while the combined treatment of ipilimumab with nivolumab significantly improves the ORR to 61% with median progression-free survival (PFS) of 11.5 months (170, 171)
Hopefully it keeps working, I'm down a few pounds already and loose stomach aside, I haven't had any other side effects
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However, as major multinational pharmaceutical companies like Novo Nordisk and Eli Lilly have reaped significant rewards in the GLP-1 market, Merck may have realized the need for a more aggressive strategy to stay competitive
Metabolic adaptation becomes more pronounced by month 3, meaning the body adjusts to lower food intake and slower weight loss rates naturally occur