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Superoxide released into the IMS can be eliminated by a different SOD isoenzyme (Cu, Zn-SOD, or SOD1), which is found in the cytoplasm of eukaryotic cells, or scavenged by cytochrome c plus cytochrome c oxidase system (Okado-Matsumoto and Fridovich, 2001)

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However, all three medications contribute significantly to weight loss and improve health outcomes among obese and overweight individuals over the long term