Liraglutide was finally approved in 2010 for the treatment of patients with type 2 diabetes unable to regulate their blood sugar with other insulin medications (Gilbert, Rosenthal, Jan 2024)
The affinity profile is calibrated for triple balance: full agonist at GIPR, full agonist at GLP-1R, partial agonist at GCGR, preserving glycemia while exploiting glucagon thermogenic benefits
If you previously reached maximum doses, you may find that a lower dose now produces the same or better effects than your pre-break maximum, which is exactly the point of the reset
This usually settles as weight stabilizes, but it needs a physician who understands both conditions
Margaret A
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