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During the initial period of using any new transdermal medication, patients may experience local skin reactions such as mild redness, itching, or irritation at the application site

The medication is taken once per week

This conversion requires the enzyme glutamatecysteine ligase (GCL, glutamate-cysteine synthase)

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A study in Tokyo involving patients with acute alcohol intoxication titled Effect of intravenous fluid therapy for acute alcohol intoxication on length of time from arrival at the emergency department until awakening by Takero Terayama, et al., 2023, found that routine IV fluid therapy did not significantly reduce the time until awakening