In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine
Furthermore, excess GSSG is postulated to result in alteration of a variety of cell functions, including enzyme function, protein synthesis, cell integrity, microtubular function, transport processes, and release mechanisms
Clements RS et al
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These models are however not suitable to study ferroptosis in the context of multi-organ injury and are not representative for critically ill patients in terms of disease etiology