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GIP enhances fat metabolism, improves insulin sensitivity in adipose tissue, and may protect against some of the nausea that pure GLP-1 agonists cause

(2011) showed that bone morphogenetic protein 7 (BMP-7), secreted by bone stromal cells, induces dormancy in prostate cancer cells via the p38 pathway and upregulation of the metastasis suppressor gene NDRG1 25

Another consequence of this shift is the changing role of clinical expertise

Phase 2 trials demonstrated an average body weight reduction of 24.2 percent at 48 weeks, surpassing every approved weight loss medication

This energy deficit, while promoting weight loss, can result in fatigue, lightheadedness, and generalized weakness, particularly during the initial weeks of treatment or after dose escalation