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PYY 136 is a gut hormone that binds to the Y1-R in pancreatic islets and central nervous system (CNS) nuclei that control appetite regulation in the brain including the brainstem area postrema (AP) and nucleus tractus solitarius (NTS), where it has an anorectic effect (Walther, Morl et al

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The drug is also known to cause headaches and bouts of dizziness