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1.2.1 The main issue is optimization of drug bioavailability The main issue for any formulation of niclosamide (and indeed other BCS Class II and IV low water-solubility drugs) is how to optimize local bioavailability

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It is a structural failure of one of the most complex and poorly vascularized tissues in the human body, and that lack of blood supply is precisely what makes disc injuries so stubbornly resistant to healing

58 In this series of 32 cadaveric knees, the augmented group demonstrated comparable strength to augmentation with an 18-gauge wire

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