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Mechanisms identified include: increased cardiac utilization of ketones increased autophagy (recycling of intracellular components)l decreased inflammation & oxidative stress improved mitochondrial function decreased intracellular Ca & Na overload decreased fibrosis improved myocardial diastolic function decrease myocardial hypertrophy Indications: Type 2 diabetes Adjunct therapy in patients not meeting their glycemic goal with other agents (e.g

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doi: 10.1038/s44324-025-00066-1

A decrease in GSH levels can upregulate the expression levels of Fas and PD-L1 in tumor cells, and block the PD-1/PD-L1 pathway through BMS-1

GLP-1 agonists slow the rate at which food and medications move through the stomach, which can theoretically reduce how much thyroid hormone is absorbedespecially if doses are not separated appropriately from meals

May support melatonin signaling and GABA-mediated relaxation