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Structural basis for the interaction of TAK1 kinase with its activating protein TAB1

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Canonical Mode of c-Met Activation Pattern The canonical mode of c-Met activation involves the binding of HGF to c-Met, which induces homodimerization and autophosphorylation of the cytoplasmic domain of c-Met and then triggers downstream signaling pathways, including the mitogen-activated protein kinase (MAPK)/extracellular signal-related kinase (ERK) (Zhang et al., 2018c) pathways (Figure 2)

10 Also, when challenged with CD4+CD45+Rb(hi) lymphocytes, these mice experienced diarrhea and demonstrated increased susceptibility to colitis