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The researchers weren't sure why

The traditional way of diagnosing vitamin B12 deficiency has been with a serum B12 blood test to determine the patients B12 levels as well as the presence of any signs or symptoms of pernicious anaemia

Without these helper molecules (coenzymes), the enzymes will not work properly (or may not work at all) to catalyze reactions that lead to energy production

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The old streams (S, ES and L) equally disappeared and, rather than being entirely decided by final examinations, 40% of the student's final grade will consist of demonstrated success over the course of the school year