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In neuronal soma and synaptic terminals, the IR participates in the restoration of cognition in the hippocampus (De Felice et al., 2022

In contrast to the acute inhibition of PDK by pyruvate, acute activation occurs via products of the PDHc as well as by fatty acid oxidation, namely acetyl-CoA and NADH

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Human CNS cultures exposed to HIV-1 gp120 reproduce dendritic injuries of HIV-1-associated dementia

This can be interpreted as a surrogate for the compounds on-target activity (Fig

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