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The most common normal localized reactions include: Redness (erythema) at the site Swelling or a small raised bump Tenderness or slight pain Mild warmth Itching Small bruising These reactions are typically: Localized to a small area (12 inches in diameter) Mild to moderate in intensity Resolve within 2448 hours Not progressively worsening Many patients will experience some degree of redness or swelling during the first week or two of therapy as the immune system acclimates

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Blood pressure and cholesterol changes often take one to three months

[13] This combination increases risk

For most individuals, an effective daily dosage ranges between 1000 mg and 3000 mg , depending on fitness goals and activity level