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N Engl J Med 389(6):514526 Muller TD et al (2022) Anti-obesity drug discovery: advances and challenges

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The fiber-vitamin group showed improvements in LDL cholesterol and apolipoprotein B while maintaining healthy HDL and triglyceride levels

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From broader hormone coverage with retatrutide, to targeting entirely new hunger signals with amycretin, to the convenience of a daily pill like orforglipron, future treatments may offer more personalized paths forward

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In March 2025, the FDA significantly expanded that indication

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