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Although SAMe has been studied as an innovative therapy for fibrosis (Czaja 2014), one systematic review of the literature was unable to confirm a statistically significant benefit in alcoholic liver disease, perhaps partially as a result of variable quality across studies (Rambaldi 2006)

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Scolyer, K.R

During ER stress, GRP78, the primary regulator of UPR, dissociates from the ER compartment, activating the main PERK protein pathway