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Under hyperglycemic conditions, RGCs exhibit significant mitochondrial impairment, including cristae dissolution, swelling, vacuolar degeneration, elevated reactive oxygen species (ROS) production, and diminished mitochondrial membrane potential (MMP) [68, 69]

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Resveratrol is a polyphenol found in plants and has been documented to suppress oxidative stress and malondialdehyde levels and restore the level of GSH (Pritam et al

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Nicotinamide N-Methyltransferase NNMT is a cytosolic methyltransferase that uses S-adenosyl-L-methionine to methylate nicotinamide

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