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As is true for many of the vitamins discovered in the early 20th century, the effects of B12 seemed miraculous, Heber explains

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Whyte 1964)

A double-blind, placebo-controlled trial in 95 patients with irritable bowel syndrome or inflammatory bowel disease and normal B12 levels found no significant improvements in fatigue, although B12 levels increased in the B12 group who received 1000 g per day per os (p.o.) for 8 weeks (form not reported)