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Their clinical use falls outside standard regulatory frameworks, and healthcare providers must ensure compliance with applicable laws and regulations

Furthermore, metformin can reverse resistance via the p53-PDK1-HKII pathway and by activating the AKT signaling pathway while inhibiting the IGF2R signaling pathway (46, 47)

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The strain can be alleviated with compositional engineering, low-temperature annealing, high TEC substrate and transporting layer selection 27