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We recently identified an acidic Asp222 residue that confers ADH activity in plant TyrAs

Studies on obese diabetic (ob/ob) mice showed that GIP (Lys16PAL) and GIP (Lys37PAL) long-acting analogs for GIPR increased the insulin response to glucose and improved glucose tolerance [58]

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In particular, it was investigated whether, in this context, DSIP can alleviate episodes of chronic pain and depressive states

The first component, cagrilintide , is a long-acting analogue of amylin a hormone co-secreted with insulin that acts at amylin and calcitonin receptors to promote satiety and slow gastric emptying

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