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Liposomal vesicle size was determined with a Submicron Particle Sizer (Nicomp Model 270) following rehydration and was found to have a mean diameter of 181.5 19.6 nm

The 2-5% impurity fraction in this range often contains a mixture of deletion sequences, oxidation products, and diketopiperazine formation byproducts

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doi: 10.1038/s41420-021-00686-8 28 PangBJinHLiaoNLiJJiangCShaoDet al