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Notably, trans-Chalcone also decreased nuclear factor B (NF-B) activation and the mRNA expression of inflammasome components such as ASC, NLRP3, pro-IL-1 and pro-caspase-1 (74)

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However, the glucuronidation pathway is not upregulated by repeated exposure to APAP [71] and is a minor pathway in babies and children, as discussed above [63,64]

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