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The Phase 2 trial data published in 2023 (Jastreboff et al., NEJM) included cardiovascular safety monitoring as a secondary endpoint

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In a recent phase II trial with subcutaneous semaglutide, when doses were escalated relatively rapidly to 16 mg weekly, participants experienced additional weight loss, but at the expense of more adverse effects (21)

Eat balanced meals at regular intervals to maintain stable blood sugar levels because low blood sugar levels can trigger headaches