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It is worth noting that about 40% of RA patients suffer from complications, and the incidence of serious complications is 8.3%, with cardiovascular disease, interstitial lung disease, osteoporosis, and metabolic syndrome predominating (Taylor et al., 2021)

STEP 1 enrolled 1,961 adults

GIP is a similar peptide hormone that regulates blood sugar and appetite

Caffeine Caffeine is a very well-known central nervous stimulant and has secondary thermogenic actions

IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a modified analog of human IGF-1 with significantly extended half-life, studied for its anabolic and metabolic effects [1]

Structure of LONP1 The nuclear gene encoding LONP1 is located on human chromosome 19 [5]