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274,275 This, in turn, diminishes additional downstream effects, including oxidative stress, the secretion of pro-degradative substances, modifications to cell phenotype (hypertrophy, M1/M2 macrophage phenotype, fibrosis), and damage or deterioration of joint cells (apoptosis, senescence)

Liver function

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular energy metabolism

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Blood GSH/GSSG ratio compared to unprotected glutathione

The main reason for using NEM, IAA or 2-VP is not the improvement of the LC and MS/MS properties of GSH, but to avoid artificial oxidation of GSH to GSSG, even if, as stated before, they are not equally effective to this purpose