2:e1501714
When it is combined with other diabetes medications, particularly insulin and insulin secretagogues, hypoglycemia can occur
Weeks 13 onward: 12mg once weekly (maximum studied dose)
Systemic effects less commonly include mild dizziness or lightheadedness (may be copper-related), temporary nausea or headache (typically resolves within hours), mild fatigue (rare, reported with higher doses), and transient flu-like symptoms (very rare, may relate to systemic inflammatory response)
However, due to a small number of animals (n = 2 per group), this was not statistically significant
The SURMOUNT-5 head-to-head comparison trial provided definitive evidence of tirzepatide's superiority over semaglutide, with Zepbound producing 20.2% average weight loss compared to 13.7% for Wegovy, a 47% greater relative reduction