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At 24 weeks, the mean change body weight was 7.2% with 1 mg, 11.8% with 4 mg (starting with 2 mg), 13.9% with 4 mg (starting with 4 mg), 16.7% with 8 mg (starting with 2 mg), 17.9% with 8 mg (starting with 4 mg), and 17.5% with 12 mg (starting with 2 mg), compared to 1.6% in the placebo group [38]

Statistical analyses were performed using GraphPad Prism (version 9.0, GraphPad Software, San Diego, CA, USA)

Diet and exercise remain the foundation

Over the past five years, all clinical trial phases have lengthened, with Phase 3 trials experiencing the most significant increaseup by 12%

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