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It's one of those things that really needs consistency

Zhdanov, A

Close Surgical Margins and Risks of Local Treatment Failure after Wedge Resection of Colorectal Pulmonary Metastases

By stimulating these centers, GLP-1 agonists promote satisfaction with smaller food portions, further supporting reduced total calorie intake

GLP-1 Receptor Pathway - Reduces hunger drive centrally (hypothalamus, brainstem) - Decreases the reward value of food (mesolimbic system) - Enhances glucose-dependent insulin secretion - Slows gastric emptying Amylin Receptor Pathway - Induces satiety through the area postrema and NTS - Activates POMC neurons (pro-satiety) and suppresses NPY/AgRP neurons (pro-hunger) in the arcuate nucleus - Additional gastric emptying delay through distinct neural circuits - Suppresses post-prandial glucagon secretion - May contribute to leptin resensitization The combination of these two pathways produces what researchers describe as broader modulation of neuroendocrine appetite control meaning amycretin hits more of the biological switches that drive eating behavior than a GLP-1-only drug can reach

High insulin levels can also increase androgen production, which can reduce how many calories your body needs to function, so you burn fewer calories at rest