In 2018, Novo Nordisk launched a TV ad campaign stating that adults lost on average up to 12 pounds when taking Ozempic
Look ARG, Wadden TA, West DS, et al
The Full GLP-1 Picture GLP-1s drive 5-18% weight loss in clinical trials, but theyre not without trade-offs
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10 Conclusions and clinical take-home messages 10.1 Main findings: certainties amidst uncertainties Synthesizing the current evidence, the information architecture regarding GLP-1RAs in PCOS fertility management exhibits a characteristic gradient: robust metabolic evidence, hypothesis-generating reproductive findings, and a gray zone of safety. Robust metabolic benefit: in overweight or obese PCOS phenotypes, evidence for the improvement of metabolic endpointsincluding body weight, central adiposity, and IRis consistently positive, facilitating the establishment of actionable therapeutic goals (e.g., reaching clinically significant weight-loss thresholds and optimizing IR markers)
Additionally, some drugs, such as recombinant LH (Musters et al., 2012
