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The key takeaway from these trials is that continued, long-term treatment is essential for maintaining the weight you've lost and even achieving further progress

Respective proportions who reached a normal LFC (defined as 5% or less) at week 24 were 0.0%, 30.8%, 53.8%, and 45.5%

Do not use Zepbound if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

NICE technology appraisal TA875 (2023) recommends semaglutide 2.4 mg (Wegovy) as an adjunct to a reduced-calorie diet and increased physical activity for adults with a BMI of 35 kg/m or above (or 3034.9 kg/m in certain circumstances) alongside at least one weight-related comorbidity, when initiated within specialist weight management services

Appetite suppression, gastrointestinal side effects, and rapid weight changes can be clinically destabilizing for individuals with current or past eating disorders

In the same study, piperlongumine also enhanced the efficacy of doxorubicin on mammary tumor growth in vivo [92]