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The differences lie in manufacturing oversight (Ozempic is FDA-approved, Strive is compounded), delivery method (Ozempic uses pre-filled pens, Strive uses multi-dose vials), formulation additions (Strive may include glycine, B12, or B6), and cost (Ozempic costs $800 to $1,200 per month without insurance versus $90 to $200 per month for Strive)

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Activation there reduces food intake, and it is this central action, as much as any peripheral effect, that drives the weight loss seen with GLP-1 drugs