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Since glutathione is one of the bodys major endogenous antioxidants and also involved in many metabolic reactions, low levels of this peptide are associated with high levels of oxidative stress and impairments in nearly every system in the body

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Redox Biol 34 , 101550 (2020)

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Subsequent increases in the permeability of the intestinal barrier in CKD patients promote the translocation of bacterial products of intestinal origin, such as LPS, uremic toxins, and cytokines, into the systemic circulation, resulting in local and systemic inflammation, as well as oxidative stress associated with CKD (Krukowski et al., 2023