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The Initial Phase: Weeks 1-4 During the first several weeks on the lowest dose, most people notice a subtle reduction in appetite, feeling fuller sooner during meals, and less interest in snacking

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Ideally, use an FDA-cleared sharps disposal container, otherwise dispose of the pen in a plastic container with a tight-fitting, puncture-resistant lid

The law (Medicare Modernization Act of 2003) explicitly excludes drugs when used for weight loss, weight gain, or anorexia. (ASPE) Some proposed changes (including reinterpreting the exclusion for obesity) were considered , but in April 2025 those were not finalized

Unlike semaglutide , which targets only the GLP-1 receptor, or tirzepatide , which targets GLP-1 and GIP receptors, retatrutide activates all three metabolic receptors at once

Side Effects That May Show Up Early Some patients may experience side effects as their body adjusts to GLP-1 therapy, including: Nausea Bloating Fatigue Headache Constipation These symptoms may improve over time for some patients, but duration varies