Blood 104:499a, 2004
What it is: Essential coenzyme for mitochondrial and DNA function How it works: Powers cellular energy (ATP) and supports brain and nerve regeneration Administration: SubQ injection Preparation: Add 5 mL bacteriostatic water to the vial
Chronic hyperglycemia can induce mitochondrial permeability transition, which compromises mitochondrial function and exacerbates cellular injury in diabetic hearts (Sloan et al., 2012)
Clin Pharmacokinet 51:553572 Rau TF, Lu Q, Sharma S, Sun X, Leary G, Beckman ML, Hou Y, Wainwright MS, Kavanaugh M, Poulsen DJ, Black SM (2012) Oxygen glucose deprivation in rat hippocampal slice cultures results in alterations in carnitine homeostasis and mitochondrial dysfunction
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Physiology and Pharmacology of DPP-4 in Glucose Homeostasis and the Treatment of Type 2 Diabetes