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As the most important intracellular antioxidant, GSH regulates all other antioxidants while preventing damage to important cellular components caused by reactive oxygen species, such as free radicals and peroxides

Starting dose matters toosome patients respond better to gradual titration from 0.25 mg weekly, while others tolerate and benefit from faster dose escalation

clinical trials showed rates similar to placebo

Several studies have shown resistance in c-Met inhibitors due to various mechanisms