canada retatrutide (20mg) Retatrutide Triple Agonist (GLP-1/GIP/GCG) |

Oral drops and sublingual formulations interact directly with the upper GI lining, which can cause more upper GI symptoms (nausea) but sometimes less lower GI disruption (constipation)

doi:10.1161/CIR.0000000000001123 Dauerman HL

J Am Coll Cardiol 2020, 76(25): 2982-3021

In addition to its insulinotropic effect, GLP-1 also act in concert with PYY and OXM to induce satiety (Figure 1)

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In clinical trials [2], the most common side effects were mild digestive issues, including: nausea diarrhoea vomiting constipation These symptoms were dose-related, usually mild to moderate, and often improved when the dose was increased more slowly