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For much of modern medical history, aging was viewed primarily as an unavoidable consequence of time

The behavioral consequence of this circuit is well-documented: optogenetic stimulation of VTA GABA neurons directly suppresses the activity and excitability of neighboring DA neurons [48] and, critically, this suppression disrupts reward consumption while leaving anticipatory behavior intact [49]

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Elsevier, pp 403425 Sharma A, Singh AK (2023) Molecular mechanism of caloric restriction mimetics-mediated neuroprotection of age-related neurodegenerative diseases: an emerging therapeutic approach

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Further, the FOXO-signaling pathway was identified to be a modulated pathway