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Suffers of the serious genetic condition phenylketonuria (PKU) are unable to convert phenylalanine to tyrosine, whilst patients with alkaptonuria have a defective tyrosine metabolism, producing distinctive urine which darkens when exposed to the air

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The scheme of Scly role in Se metabolism is demonstrated in Figure 3 (Seale, 2019)

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and the direct reduction of mitochondrial glutaredoxin 2 (Grx2) by TrxR is also of important physiological relevance (Johansson et al., 2004

For further reading on the benefits of glutathione, see this review of glutathione as an antioxidant in health and wellness