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Any form of ingestion, injection, inhalation, topical application, implantation, or bodily introduction into humans or animals is strictly prohibited

During the past several years we have created mathematical models for different parts of one-carbon metabolism [1621]

The therapeutic window is narrow, the degradation pathways are enzymatic and irreversible, and the difference between a successful study and a null result often comes down to whether the investigator understood that plasma half-life and biological activity duration are not the same measurement

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DOI: 10.1016/j.chroma.2006.05.063

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