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doi: 10.1007/s00344-019-09981-2 30 HnschR.MendelR

Hall MJ, Levant S, DeFrances CJ

In Kupffer cells, NRF2 and NF-B represent two pivotal transcription factors that play contrasting roles in the regulation of inflammation

In summary, our in vitro results support our hypothesis that LDHB, analogous to FSP1, transports reducing equivalents of NADH to CoQ into the lipid bilayer, thereby facilitating CoQH2-mediated inhibition of lipid peroxidation

It also includes hair follicles, sweat glands, and sebaceous glands

It was reported that it could raise intracellular GSH by increasing SLC7A11 expression, efficiently leading to GPX4 enhancement and ferroptosis suppression in the ISO-induced injury model of H9C2 cells and rat myocardium [49]