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Accumulating evidence suggests that mTOR/S6K signaling is involved in diabetes, cancer, and obesity (Tavares et al., 2015)

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Evening injection timing requires discipline to maintain a consistent schedule, and some patients find it harder to remember a nighttime task if they travel frequently or work irregular shifts

References 1 and 2 are classic papers describing both the general nature of the oxygen effect in reducing radiation sensitivity (reference 2) and the fact that the hypoxic cells almost certainly are present in human tumours (reference 1)

The fibroblast layer sits 100 to 1,000 micrometers below the skin surface

This timeframe allows assessment of individual response, opportunity to adjust dosing, and generation of meaningful results without committing to an extended protocol