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In addition, (1 S , 2 S )-2-(2-( N -[(3-benzimidazol-2-yl)propyl]- N -methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride (NNC), a small-molecule inhibitor of the PEX3-PEX19 interaction critical for peroxisome biogenesis, restored the sensitivity of MAPKi-resistant melanoma to MAPKi
The histamine released causes blood vessel dilation (redness), increased vascular permeability (swelling), and nerve ending stimulation (itching and pain)
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