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At 24 weeks, average weight loss was: At 48 weeks, average weight loss was: The study also found that, at 48 weeks, 100% of people taking 12mg lost at least 5% of their body weight , 93% lost at least 10% , and 83% lost at least 15%

For tirzepatide, this might mean escalating to 10-15 mg for active weight loss, then reducing to 5-7.5 mg for maintenance

While occasional muscle cramps are common and often benign, persistent or severe cramping may indicate electrolyte imbalances, peripheral neuropathy, or other underlying conditions requiring specific treatment

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