Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome
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For mild injection site reactions: Cold compresses applied to the affected area for 1015 minutes can reduce swelling and discomfort Topical emollients to soothe irritated skin Oral antihistamines (such as cetirizine 10mg once daily or loratadine 10mg once daily) may help with itching Injection technique optimisation ensure proper rotation of injection sites (abdomen, thigh, or upper arm), inject at room temperature, and use correct subcutaneous technique Observation many mild reactions resolve spontaneously without intervention For moderate allergic reactions: If you develop urticaria or more widespread rash without severe symptoms, your GP may consider: Non-sedating antihistamines at standard doses as per BNF guidance Short course of oral corticosteroids may be prescribed in selected cases after clinical assessment, though not routinely indicated for all skin reactions Topical corticosteroids (moderate potency) for localised rash Your healthcare provider will need to assess whether continuing Ozempic is appropriate or whether the medication should be discontinued
Ona VO, Li M, Vonsattel JPG, Andrews LJ, Khan SQ, Chung WM, et al
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