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Although the role of ADE in long COVID is less well-characterized, limited evidence suggests that ADE-associated antibodies, such as anti-nucleocapsid antibodies, may contribute to disease pathogenesis primarily through immune activation (mechanism illustrated in Figure 1B) [85,86,87]

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To enhance the oral absorbtion of the drug, metformin prodrugs were developed with improved permeability across the lipid membrane 120

doi: 10.1038/s41392-024-01772-w 36 KangYPMockabee-MaciasAJiangCFalzoneAPrieto-FariguaNStoneEet al

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