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These four mechanisms operate on distinct molecular targets, which minimizes theoretical pathway competition and provides the rationale for multi-component research models

Numerous studies (135-178) have indicated that GLP-1RAs can reduce oxidative stress, inflammatory responses, apoptosis and mitochondrial dysfunction, improve insulin resistance, and induce myogenic differentiation, thereby showing potential in the treatment of SIM

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'Anatomy and regulation of the central melanocortin system.' Nature Neuroscience

TLS are mainly composed of lymphocytes and are supported, structurally and functionally, by fibroblasts with distinct phenotypes