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DSIP showed potential in early animal and small human trials to decrease sleep latency and improve the depth and efficiency of sleep

[10]Morris, Pip A

10.1046/j.1601-183x.2003.00054.x Genes Brain Behav

This process of retrograde signaling or mitochondria talking to the nucleus is a newly recognized aspect of cell biology, and MOTS-c is one of the best examples we know of