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Thats the problem with berberine and all of these herbal substances theyre typically not rigorously studied in the type of large, randomized clinical trials that we put actual drugs through

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Although definitive GLP-1 randomized clinical trials remain limited, it might be very good news for patients, just like the invention of naltrexone, which also treats alcohol and opioid addictions

Heres what happens when you take GLP-1 drugs: Appetite signals soften, so you feel full sooner (NIH) Cravings, especially for high-calorie foods, often decrease (NIH) Blood sugar spikes become more controlled (NIH) Digestion slows, extending satiety after meals (NIH) This is why GLP-1 weight loss feels different from traditional dieting