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Other intermembrane proteins released into the cytosol such as cytochrome c and Smac/DIABLO, do not promote apoptosis because APAP-induced mitochondrial dysfunction and oxidant stress prevents any apoptotic signaling in hepatocytes [54, 55]

Another important form of NO-related posttranslational modification (PTM) is protein S-nitrosylation (SNO), a product of the interaction of NO with the sulfhydryl groups of cysteine which leads to the formation of S-nitrosothiols [147, 159]

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LiuYYiehLYangTDrinkenburgWPeetersPStecklerTet alMetabolomic biosignature differentiates melancholic depressive patients from healthy controls

In mammals, excess purine nucleosides are removed from the body by breakdown in the liver and excretion from the kidneys